Mutation Spectra Studies of Tumor Suppressor Genes Molecular Epidemiology of Human Cancer: Contribution of Updated Version
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Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes.
The identification of individuals at high risk of cancer can offer promising avenues for the prevention of cancer. The majority of human cancer cases are caused by environmental, occupational, and recreational exposures to carcinogens (1). These carcinogens can affect one or multiple stages of carcinogenesis through both genetic and epigenetic mechanisms (2-4). Cancer risk assessment, a highly ...
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Background &Aims: Laryngeal cancer is the second common cancer of respiratory tract, following the lung cancer. Carcinogenesis is a complex multistage process; molecular genetics has provided the evidence that activation of proto-oncogene and loss or inactivation of tumor suppressor genes (TSG) are involved in a large number of malignancies. One of the earliest significant tumor suppressor gene...
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Introduction: Despite improvements in the diagnosis and treatment of lung cancer in the past two decades, it has remained the most common cause of death from cancer worldwide. Among all genes that are mutated in lung cancer, TP53 located on chromosome 17P13/1 has a significant diagnostic and prognostic value. TP53 mutations have been extensively studied in lung cancer and TP53 mutational spectr...
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Objective(s) P53 is an important tumor suppressor, which is mutated in later stages of many cancers and leads to resistance to chemotherapy. The aim of this study was to reveal mutations of TP53 in colorectal cancer in Kerman province. Materials and Methods A total of Forty-three colon cancer specimens as paraffin block or fresh tissues, which passed stage IIIA, were selected. Three exons 5,...
متن کاملFrom gene to carcinogen: a rapidly evolving field in molecular epidemiology.
Chemical and physical carcinogens leave footprints of their activities on DNA because of the patterns of base changes they induce. Additionally, the conversion of 5-methylcytosine to thymine in CpG sequences leads to a characteristic mutation which can be used to estimate the contribution of endogenous processes to human mutations. Knowledge of the pattern mutations found in genes commonly muta...
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